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Cambridge MedChem Consulting

Medicines Used

We often see news stories about the "biggest" drugs based on sales, however this way of looking at drug sales is somewhat skewed by the high cost of some therapeutics, particularly biologics. It is also noteworthy that the majority of the drugs are indicated for cancer.

Drug Indication Worldwide Sales 2018
Humira Rheumatoid Arthritis $19.936 billion
Eliquis Anticoagulant  $9.872 billion
Revlimid Cancer $9.685 billion
Opdivo Cancer $7.570 billion
Keytruda Cancer $7.171 billion
Enbrel Rheumatoid Arthritis $7.126 billion
Herceptin Cancer $6.981 billion
Avastin Cancer $6.847 billion
Rituxan Cancer $6.750 billion
Xarelto Anticoagulant 6.589 billion
Eylea Cancer/AMD $6.551 billion
Remicade Crohn's Disease $5.908 billion
Prevnar 13 Pneumonia $5.802 billion
Stelara Psoriasis  $5.156 billion
Lyrica Epilepsy/Pain $4.970 billion

I can't help but think that a better metric might be the number of patients treated. Whilst I don't have access to worldwide prescriptions the NHS in the UK does provide some information as part of the Prescription cost analysis for 2018. Whilst the number of prescriptions does correspond exactly with the number of patients treated I suspect it gives a very good indication.

Looking at the categories of drugs it is interesting to note that cancer does not figure in the top 20 categories. As you might expect lipid-lowering drugs, gastric ulcer treatment, treatments for cardiovascular disease, anti-depressants and analgesics are the most prescribed.

Drug Category Number of items
Lipid-Regulating Drugs 74,289,246
Proton Pump Inhibitors 60,024,837
Angiotensin-Converting Enzyme Inhibitors 44,159,042
Calcium-Channel Blockers 41,102,081
Beta-Adrenoceptor Blocking Drugs 38,617,728
Selective Serotonin Re-Uptake Inhibitors 38,216,924
Non-Opioid Analgesics And Compound Prep 35,998,332
Antiplatelet Drugs 34,139,843
Thyroid Hormones 32,253,535
Control Of Epilepsy 27,989,893
Vitamin D 24,559,380
Opioid Analgesics 23,393,193
Selective Beta(2)-Agonists 22,900,805
Biguanides 21,806,787
Corticosteroids (Respiratory) 20,879,110
Angiotensin-II Receptor Antagonists 20,499,156
Oral Anticoagulants 17,613,257
Tricyclic & Related Antidepressant Drugs 16,704,980
Other Antidepressant Drugs 15,911,182
Thiazides And Related Diuretics 14,628,130
Antihistamines 13,626,254

Looking at the top most prescribed drugs, small molecule drugs dominate for all indications.

Chemical Name Indication Items
Atorvastatin Lipid-Regulating Drugs 41,820,664
Levothyroxine Sodium Thyroid Hormones 32,187,950
Omeprazole Proton Pump Inhibitors 31,038,076
Amlodipine Calcium-Channel Blockers 29,052,338
Ramipril Angiotensin-Converting Enzyme Inhibitors 28,605,025
Lansoprazole Proton Pump Inhibitors 25,461,167
Simvastatin Lipid-Regulating Drugs 24,303,261
Bisoprolol Fumarate Beta-Adrenoceptor Blocking Drugs 23,625,562
Colecalciferol Vitamin D 23,609,903
Aspirin Non-Opioid Analgesics And Compound Prep 23,397,042
Metformin Hydrochloride Diabetes 21,806,787
Salbutamol Selective Beta(2)-Agonists 21,577,054
Paracetamol Non-Opioid Analgesics And Compound Prep 18,516,491
Co-Codamol (Codeine Phos/Paracetamol) Opioid Analgesics 15,179,951
Sertraline Hydrochloride Selective Serotonin Re-Uptake Inhibitors 14,815,719
Citalopram Hydrobromide Selective Serotonin Re-Uptake Inhibitors 14,136,645
Amitriptyline Hydrochloride Tricyclic & Related Antidepressant Drugs 13,532,567
Furosemide Thiazides And Related Diuretics 11,945,445
Beclometasone Dipropionate Corticosteroids (Respiratory) 10,671,698

Also of note is the number of prescriptions for drugs that are readily available over the counter.

No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples

For depression, SLC6A4 seemed like a great candidate and was supported by very early gene studies

BUT….

Am J Psychiatry. 2019 May 1;176(5):376-387. DOI

The study results do not support previous depression candidate gene findings, in which large genetic effects are frequently reported in samples orders of magnitude smaller than those examined here. Instead, the results suggest that early hypotheses about depression candidate genes were incorrect and that the large number of associations reported in the depression candidate gene literature are likely to be false positives.

How many other early gene disease association studies need to be checked?

Updated Drug Discovery Resources

I've done some updates to the Drug Discovery Resources.

The Following Pages have been Updated

Macrocycles
Predicting Metabolism
Covalent Inhibitors

PROteolysis TArgeting Chimeras (PROTACs), Lysosome Targeting Chimeras (LYTACs), and ENDosome TArgeting Chimeras (ENDTACs)

Twenty Years of the Rule of Five

RSC-BMCS and RSC-CICAG are delighted to announce registration is now open for Twenty Years of the Rule of Five, Wednesday, 20th November 2019, Sygnature Discovery, BioCity, Nottingham, UK. #RuleofFive2019

It has been over twenty years since Lipinski published his work determining the properties of drug molecules associated with good solubility and permeability. Since then, there have been a number of additions and expansions to these “rules”. There has also been keen interest in the application of these guidelines in the drug discovery process and how these apply to new emerging chemical structures such as macrocycles.

Ro5-webimage-2

This symposium will bring together researchers from a number of different areas of drug discovery and will provide a historical overview of the use of Lipinski’s rules, as well as looking to the future and how we use these rules in the changing drug compound landscape.

Full details and registration are here https://www.maggichurchouseevents.co.uk/bmcs/twenty-years-Ro5.htm.

Cathepsin C inhibitor chemical probe

As part of the Boehringer Ingelheim's efforts to foster innovation, they are share selected molecules with the scientific community all for free. The opnme portal gives access to a range of novel ligands. The latest addition is BI-9740

BI-9740 is a very potent and highly selective inhibitor of the enzymatic activity of Cathepsin C. It blocks human CatC in vitro with an IC50 of 1.8 nM and shows > 1500x selectivity versus the related proteases Cathepsin B, F, H, K, L and S. BI-9740 displays no activity against 34 unrelated proteases from different classes up to a concentration of 10 µM.

BI9740

Chemical probes are absolutely essential for target validation and it is great to see so many high quality tools being made available.

European Lead Factory update

The European Lead Factory (ELF) secured a total project budget of EUR 36.5 million under the second framework of the Innovative Medicines Initiative (IMI). 20 partners in 7 countries will push forward the transformation of potential drug targets to new medicines in the new project ESCulab (European Screening Centre: unique library for attractive biology) under the European Lead Factory brand.

Full details here https://www.europeanleadfactory.eu/news-events/european-lead-factory-europe’s-largest-collaborative-drug-discovery-platform-continues.

Over the next five years, the European Lead Factory will initiate 185 new drug discovery projects by screening medically relevant drug targets from European researchers, small and medium-sized enterprises and pharmaceutical industry against the ELF library of 550,000 unique chemical compounds.

European universities dismal at reporting results of clinical trials

Clinical trial data is some of the most important information in Drug Discovery, after all it is humans we are looking to treat! However analysis of 30 leading institutions found that just 17% of study results had been posted online. The 30 universities surveyed are those that sponsor the most clinical trials in the EU. Fourteen of these institutions had failed to publish a single results summary.

Screenshot 2019-04-30 at 17.31.28

The Universities that have failed to publish a single trial result are highlighted in red in the table below.

Screenshot 2019-04-30 at 17.32.57

The contrast between the UK universities and the rest of Europe could not be starker,

UK universities in the survey performed significantly better than those in the rest of Europe. The University of Oxford and King’s College London had both published 93% of the trial results due on the register, and University College London had posted 81%.

According to the report every single medical university in the UK is currently working hard to upload missing clinical trial results onto the EU registry, and in many cases onto other registries such as ISRCTN and the US registry Clinicaltrials.gov as well. This demonstrates that where there is a will, there is a way.

If we remove the UK Universities from the analysis the level of reporting falls to a pitiful 7%.

Lack of transparency in clinical trials harms patients. The timely posting of summary results is an ethical and scientific obligation.


2nd RSC-BMCS / RSC-CICAG Artificial Intelligence in Chemistry

The lineup for the 2nd RSC-BMCS / RSC-CICAG Artificial Intelligence in Chemistry Monday-Tuesday, 2nd to 3rd September 2019 Fitzwilliam College, Cambridge, UK has been updated.

AI-webpage-image

Twitter #AIChem19

Artificial Intelligence is presently experiencing a renaissance in development of new methods and practical applications to ongoing challenges in Chemistry. Following the success of the inaugural “Artificial Intelligence in Chemistry” meeting in 2018, we are pleased to announce that the Biological & Medicinal Chemistry Sector (BMCS) and Chemical Information & Computer Applications Group (CICAG) of the Royal Society of Chemistry are once again organising a conference to present the current efforts in applying these new methods. The meeting will be held over two days and will combine aspects of artificial intelligence and deep machine learning methods to applications in chemistry.

Speakers

Deep learning applied to ligand-based de novo design: a real-life lead optimization case study, Quentin Perron, IKTOS, USA
A Turing test for molecular generators, Jacob Bush, GlaxoSmithKline, UK
Presentation title to be confirmed, Keynote: Regina Barzilay, Massachusetts Institute of Technology, USA
Artificial intelligence for predicting molecular Electrostatic Potentials (ESPs): a step towards developing ESP-guided knowledge-based scoring functions, Prakash Rathi, Astex Pharmaceuticals, UK
Molecular transformer for chemical reaction prediction and uncertainty estimation, Alpha Lee, University of Cambridge, UK
Drug discovery disrupted - quantum physics meets machine learning, Noor Shaker, GTN, UK
Presentation title to be confirmed, Christian Tyrchan, AstraZeneca,
Presentation title to be confirmed, Anthony Nicholls, OpenEye Scientific Software, USA
Deep generative models for 3D compound design from fragment screens, Fergus Imrie, University of Oxford, UK
DeeplyTough: learning to structurally compare protein binding sites, Joshua Meyers, BenevolentAI, UK
Presentation title to be confirmed, Maciej Haranczyk, IMDEA, Spain
Deep learning for drug discovery, Keynote:  David Koes, University of Pittsburgh, USA
Presentation title to be confirmed, Olexandr Isayev, University of North Carolina at Chapel Hill, USA
Dreaming functional molecules with generative ML models, Christoph Kreisbeck, Kebotix, USA
Presentation title to be confirmed, Keynote:  Adrian Roitberg, University of Florida, USA

Applications for poster presentations are welcomed, the closing date for submission is 5th July. A number of RSC-BMCS and RSC-CICAG student bursaries are available up to a value of £250, to support registration, travel and accommodation costs for PhD and post-doctoral applicants studying at European academic institutions. The closing date for bursary applications is 15th July.

Full details are on the conference website





Atomwise AIMS awards

AIMS-Infographic_Spring2019@0,33x-2 (1)

I suspect many will have noticed the recent announcement of the Early Results in Drug Discovery Partnership with AI Biotech Company. These are the first results of the Atomwise AIMS awards:

The researchers have been using Atomwise’s AI-powered in silico screening technology to develop therapeutic treatments for, among others, certain types of strokes, hand-foot-and-mouth disease, and an infection that causes reproductive failure in pigs.

The AIMS award program is a great opportunity for university research scientists to easily access AI-assisted structure-based virtual screening technology:

  • Customized small molecule virtual screen using AtomNet™ technology
  • 72 small molecules predicted to bind to a specific target protein – QC verified by mass spectrophotometry, resuspended and diluted to a convenient concentration, aliquoted into microtiter plates, and delivered at no cost to the researcher
  • Support from Atomwise’s medicinal chemists and structural biologists
  • Opportunity to receive up to $30K USD to subsidize assay work

If you have a target protein with an X-ray crystal, Cryo-EM, or NMR structure, or with close sequence homology to a protein with available structures, and an assay in place to evaluate 72 potential hits, then you should consider applying.

Full details are on the AIMs awards page and the closing date is 29 April 2019.



OpenSource Antibiotics

I just thought I’d highlight a new project I’m involved with.

Open Source Antibiotics (https://github.com/opensourceantibiotics) is intended to be a platform for a collaborative effort towards antibiotic discovery.

373siteview

The first projects have been initiated

Mur Ligase (https://github.com/opensourceantibiotics/murligase) and the background to these exciting targets can be found on the wiki page.

https://github.com/opensourceantibiotics/murligase/wiki

This also provides details of the first two fragment screens.

MurD https://github.com/opensourceantibiotics/murligase/wiki/MurD-fragment-screen

and

MurE https://github.com/opensourceantibiotics/murligase/wiki/MurE-fragment-screen

What we want now is for people to join in and suggest the next round of fragments that should be screened. Ideally these should be commercially available but if people want to design, make and submit their own fragments we would be happy to screen them.

If you feel appropriate, we would appreciate any publicity on this exciting new project