9th Fragment-based Drug Discovery Meeting slides
I'm just back from the 9th Fragment-based Drug Discovery Meeting https://www.rscbmcs.org/events/fragments24/ another fabulous meeting and always great to hear about the multitude of ways that Fragments are impacting drug discovery, from target identification, hit discovery to lead optimisation. A number of people asked if the slides from my talk would be available.
Hopefully this link will be accessible to everyone.
http://cambridgemedchemconsulting.com/news/files/FragHitsMar2024.pdf.
BMCS Hot Topics Meetings
The next meeting is Hot Topics: Covalent Drug Discovery 2024, this online event is on Thursday 16th May, 2024 (afternoon).
To register for the meeting, click here To download the first announcement poster, click here
UKQSAR meeting University of Liverpool on September 14th 2023.
The next UKQSAR meeting will be held at the University of Liverpool on September 14th 2023.
The meeting will take place at building 502, University of Liverpool (see D6 in campus map).
More information will be available on the website https://ukqsar.org/index.php/2023/07/19/uk-qsar-autumn-2023-meeting/
The schedule will be:
9.00-10.00 Registration (coffee/tea/refreshments) 10.00-10.15 Welcome – Nathan Brown (UK QSAR Chair)
10.15-11.45 Session 1 – Chair Neil Berry (University of Liverpool) 10.15-10.45 Talk 1– Alessandro Troisi (University of Liverpool) 10.45-11.15 Talk 2 – Abbie Trewin (University of Lancaster) 11.15-11.45 Talk 3 – Lauren Reid (Medchemica Ltd.) 11.45-12.45 Lunch and poster session
12.45-13.45 Session 2 – Chair Andrew Leach (University of Manchester) 12.45-13.15 Talk 4 – Steve Enoch (Liverpool John Moores University) 13.15-13.45 Talk 5 – Rachel Pirie (University of Newcastle) 13.45-14.15 Break (coffee/tea/refreshments) and poster session
14.15-15.45 Session 3 – Chair Steve Maginn (CCG) 14.15-15.15 Talk 6 – Elena De Orbe (AstraZeneca Ltd.) 15.15-15.45 Talk 7 – Adam Nelson (University of Leeds) 15.45-16.00 Conclusion and poster prizes - Nathan Brown (UK QSAR Chair)
Please register using the online form.
We are delighted that the RSC CICAG group (Chemical Information and Computer Applications Group) have been able to offer two travel bursaries for students to attend the meeting in return for providing a short write-up for the group. If you would like to apply for the bursary please use the form
UKQSAR meeting Sept 2023
Just got this message, the UKQSAR meetings are always excellent
We are pleased to announce that the next UKQSAR meeting will be held at the University of Liverpool on September 14th 2023.
The schedule will be: 09.00-10.00 Registration 10.00-16.00 Scientific programme
Please register using the online form: https://forms.office.com/e/RR5qGKGCwJ
We are delighted that the RSC CICAG group (Chemical Information and Computer Applications Group (rsccicag.org) have been able to offer two travel bursaries for students to attend the meeting in return for providing a short write-up for the group. If you would like to apply for the bursary please use the form: https://forms.office.com/e/yiNi4VFuZD
As usual, there is no cost to register for the meeting and we are grateful for MedChemica Ltd. for supporting the catering costs.
There will be plenty of opportunity for posters to be presented and discussed over lunch and coffee, please indicate if you would like to present a poster in the registration.
Information about travel options are available from the University of Liverpool website: https://www.liverpool.ac.uk/study/international/coming-to-liverpool/getting-here/ https://www.liverpool.ac.uk/maps/visiting/car-parking/ We would urge you to consider the environment when planning your journey.
Hot Topics: Targeting RNA 2023
A new initiative from the RSC BMCS. The BMCS Hot Topics online meetings are intended to highlight breaking areas of research in fields of science relevant to drug discovery. They will run as stand-alone half-day virtual events, 2-3 times per year.
The inaugural meeting on 30th November 2023 will cover relevant methods and modes of targeting RNA in drug discovery and will focus on how small molecules can accomplish this, including RNA binding and degradation, splicing modulation, and enzymes modifying RNA.
The first circular and registration can be found here https://www.rscbmcs.org/events/hottopicsrna23/.
Matthew Disney, University of Florida, Design of Bioactive Small Molecules Targeting RNA.
Elliott Bayle, Storm Therapeutics, Targeting RNA Modifying Enzymes: Successes, Challenges and Lessons Learned.
Maria Duca, Université Côte d’Azur – CNRS, Design of multifunctional conjugates for the targeting of non-coding RNAs: anticancer and antimicrobial applications.
Cambridge MedChem Meeting
Registration for the SCI / RSC 22nd Medicinal Chemistry Symposium (better known as The Cambridge MedChem Meeting) 10 September - 13 September 2023 is now open.
As usual there are discounts available for RSC and SCI members, and RSC members need to use a discount code
RSC members should enter the Event discount code EJRFChem221 and select “Guest Member” under the section Member type. Delegates will be contacted for their RSC membership number after successful registration. RSC student members should enter the Event discount code EJRFChem221S and select “Guest Member” under the section Member type. Delegates will be contacted for their RSC membership number after successful registration.
You can register here https://www.soci.org/events/fine-chemicals-group/2023/sci--rsc-22nd-medicinal-chemistry-symposium.
As usual there is an outstanding lineup of international speakers.
As part of the conference, there is also the opportunity to participate in a Medicinal Chemistry Workshop which will take place on the Sunday afternoon.
Ultra large Chemical Libraries
In a recent blog post Derek Lowe talked about "Virtual Screening Versus the Numbers" https://www.science.org/content/blog-post/virtual-screening-versus-numbers highlighting some of the issues around ultra large chemical libraries.
It seems quite timely that RSC CICAG is organising a meeting on Ultra Large Chemical libraries 10 August 2022 10:00-17:00, Burlington House, London, United Kingdom.
A decade ago a chemical library of a million compounds was considered large but over the last few years there has been a period of continuous growth in the size of both physical and virtual chemical libraries. As the libraries have grown the conventional search technologies have become unsustainable and new technologies are needed. This meeting will look at the challenges and solutions used to design, create, compare and search these ultra-large chemical libraries.
There are more details and registration here https://www.rsc.org/events/detail/73675/ultra-large-chemical-libraries.
It is now open for abstract submission (oral due by May 1st, posters June 2nd).
Registration fees
Delegate member early £95
Delegate non-member early £115
Delegate member std £120
Delegate non-member std £145
Student member early £65
Student non-member early £85
Student member std £90
Student non-member std £110
6th RSC-BMCS Symposium on Mastering MedChem
The 6th RSC-BMCS symposium on mastering medicinal chemistry, a virtual event Tuesday & Wednesday, 29th & 30th June 2021 (two afternoon sessions).
This is a fantastic opportunity, two days of high quality presentations, the best way to learn MedChem is to listen to Case Histories. Details are here https://www.cathyhillevents.co.uk/BMCS/MMCVI.html.
You can register here https://www.maggichurchouseevents.co.uk/bmcs/MMCVI-online_registration.htm.
21st RSC / SCI Medicinal Chemistry Symposium
Registration for the 21st RSC / SCI Medicinal Chemistry Symposium Monday-Wednesday, 13th-15th September 2021 hosted at Churchill College, Cambridge, UK is now open. Twitter hashtag - #CamMedChem21
As usual there is a stella lineup of presentations and there is still time for some submissions.
I'd like to highlight one talk that is close to my heart. Ed Griffen will talking about The COVID Moonshot: SARS-CoV2 oral antiviral therapeutics from an Open Science global collaboration.
The COVID Moonshot is an ambitious crowdsourced initiative to accelerate the development of a COVID antiviral. We work in the open with no intellectual property constraints. This way, any scientist can view submitted drug designs and experimental data to inspire new design ideas. We use our cutting-edge machine learning tools and Folding@home's crowdsourced supercomputer to determine which drug designs to send to our partners to make and test in the lab. With each drug design tested, we get closer to our goal.
This talk will be in the late breaker session and because of the open nature of the project it will be a chance to really see the very latest results "hot off the press".
You can have a look at the latest results here now. https://covid.postera.ai/covid.
30th April: Late breaker and early poster deadline
23rd July: Final poster deadline
Registration link https://www.maggichurchouseevents.co.uk/bmcs/cmc21/index.htm
AI3SD Online Guest Lecture Series
Artificial Intelligence and Augmented Intelligence for Automated Investigations for Scientific Discovery (AI3SD) are running an Online Guest Lecture Series this summer. The full seminar list is here.
http://www.ai3sd.org/summer-seminar-series-2020.
If you missed a presentation or want to replay it, all the presentations are on the AI3SD YouTube channel.
21st RSC/SCI Cambridge MedChem Meeting
The first circular for the 21st Cambridge MedChem Meeting, 12-15th September 2021, Churchill College, Cambridge. #CamMedChem21
Full details on the website.
'In Silico Toxicology' Network Meeting 2020
The 'In Silico Toxicology' Network Meeting 2020 will be held on 30 September 2020, 10am-5pm (UK time).
On Zoom this year, and open to all (max 300 participants) more details and registration here http://www.drugdiscovery.net/tox2020/.
An event (with free registration) to foster the In silico Toxicology Community in the UK and beyond. Scientific contributions are welcome as are those on ongoing work, regulatory aspects, industry perspectives, databases, relevant software, etc. in the field. This event is meant to stimulate interactions and discussions, hence speakers are asked to present both about successes and applications that work, as well as areas where still further work is needed, in order to truly develop the field in the future.
SCI-RSC Workshop on Computational Tools for Drug Discovery 2020
The SCI Fine Chemicals Group and RSC Chemical Information and Computer Applications Group are organising a second Workshop on Computational Tools for Drug Discovery. The meeting format will be the same as the very successful meeting run in Birmingham in 2019.
The 2020 workshop will be held on 19 May 2020 at Riverside West, Whitehall Road, Leeds , West Yorkshire, LS1 4AW.
The 2020 workshop will be held on 19 May 2020 at Riverside West, Whitehall Road, Leeds , West Yorkshire, LS1 4AW,
The Workshop Providers and Facilitators are
- Al Dossetter, MedChemica
- Greg Landrum, KNIME
- Gunther Stahl, OpenEye
- Ilenia Giangreco, CCDC
- Matt Segall, Optibrium
- Stuart Firth-Clark, Cresset
Attendees will be able to choose from 4 of 6 sessions.
To select which workshops you would like to attend for each session, please complete the survey on the website. Please note that spaces are allocated on a first-come, first-served basis.
More details of the workshops and registration details are on the website shown below
https://www.soci.org/events/scirsc-workshop-on-computational-tools-for-drug-discovery.
31st symposium on Medicinal Chemistry in Eastern England
The Symposium on Medicinal Chemistry in Eastern England, known colloquially as the "Hatfield MedChem" meeting, is a highly successful, long-standing, one-day meeting which runs annually. The scientific program comprises of presentations showcasing medicinal chemistry case studies from tools to candidates, across a range of modalities, therapeutic areas and target classes, as well as covering more general topics from the forefront of drug discovery of relevance to medicinal chemists. The meeting aims to be informal and interactive and the event will offer excellent scientific and networking opportunities for all those working in medicinal chemistry and drug discovery.
It will take place on Thursday 30th April 2020 at The Fielder Centre, Hatfield, Hertfordshire, UK
Registration is now open.
Full details of the scientific programme and registration details are on the website https://www.maggichurchouseevents.co.uk/bmcs/hatfield_symposium-31.htm
Always a very popular meeting so registration early is recommended.
Twitter hashtag #HatfieldMedChem20
20 Years of Rule of 5 Meeting Report
It has been over twenty years since Lipinski published his work determining the properties of drug molecules associated with good solubility and permeability. Since then, there have been a number of additions and expansions to these “rules”. There has also been keen interest in the application of these guidelines in the drug discovery process and how these apply to new emerging chemical structures such as macrocycles. This symposium brought together researchers from a number of different areas of drug discovery and provided a historical overview of the use of Lipinski’s rules, as well as looking to the future and how we use these rules in the changing drug compound landscape.
The 20 Years of the Rule of Five Meeting brought together researchers from a number of different areas of drug discovery and provided both a historical overview of the use of Lipinski’s rules, as well as looking to the future and how these rules might evolve in the changing drug compound landscape. The meeting had a capacity attendance of over 100, with Sygnature kindly providing the venue. The audience was a nice mix of industry “veterans”, students and those new to the industry. The meeting format was a morning session giving a historical viewpoint followed by a panel discussion, and the afternoon was dedicated by a more forward looking session again followed by a panel discussion.
The full report is here in PDF format Full Report, many thanks to the presenters for permission to use the images.
More details and the available slide decks are here, Twitter hashtag - #RuleofFive2019.
Upcoming Conferences
I just thought I'd mention a couple of meetings I'm helping to organise.
2nd RSC-BMCS / RSC-CICAG Artificial Intelligence in Chemistry
Artificial Intelligence is presently experiencing a renaissance in development of new methods and practical applications to ongoing challenges in Chemistry. Following the success of the inaugural “Artificial Intelligence in Chemistry” meeting in 2018 a second meeting has been organised at Fitzwilliam College, Cambridge (2nd to 3rd September 2019). The lineup is now finalised and looks like a great selection of speakers. There is still time to submit posters (closing date 5th July).
Registration is open and there are discounts for RSC members.
The Twitter hashtag - #AIChem19 is already being actively used.
20th SCI/RSC Medicinal Chemistry Symposium
This is Europe’s premier biennial Medicinal Chemistry event, focussing on first disclosures and new strategies in Medicinal Chemistry. It takes place a Churchill College, Cambridge UK, 8 September - 11 September 2019. There is a fantastic lineup of speakers and looks to be one of the highlights of the MedChem calendar. Early career scientists can also take part in a Medicinal chemistry workshop on the Sunday afternoon, a great way for people to learn medicinal chemistry and meet other scientists in a fun and informal setting.
You can register here both RSC and SCI members get a reduced rate, and despite the slightly confusing page on the SCI website you don't have to be a member to attend, just select "Event Member FREE from the dropdown menu and you can register for the event without membership.
Twenty Years of the Rule of Five
It has been over twenty years since Lipinski published his work determining the properties of drug molecules associated with good solubility and permeability. Since then, there have been a number of additions and expansions to these “rules”. There has also been keen interest in the application of these guidelines in the drug discovery process and how these apply to new emerging chemical structures such as macrocycles.
This meeting aims to have a look at the impact the Ro5 has had on drug discovery and as well as looking to the future and how we use these rules in the changing drug compound landscape as drug discovery moves into novel areas of chemistry.
There is a very exciting group of speakers and the timetable has been designed to allow a panel discussion after each session. Given the topic and the speakers I'm sure these will be entertaining sessions.
You can register here and there are discounts for RSC members
Twitter hashtag - #RuleofFive2019
Twenty Years of the Rule of Five
RSC-BMCS and RSC-CICAG are delighted to announce registration is now open for Twenty Years of the Rule of Five, Wednesday, 20th November 2019, Sygnature Discovery, BioCity, Nottingham, UK. #RuleofFive2019
It has been over twenty years since Lipinski published his work determining the properties of drug molecules associated with good solubility and permeability. Since then, there have been a number of additions and expansions to these “rules”. There has also been keen interest in the application of these guidelines in the drug discovery process and how these apply to new emerging chemical structures such as macrocycles.
This symposium will bring together researchers from a number of different areas of drug discovery and will provide a historical overview of the use of Lipinski’s rules, as well as looking to the future and how we use these rules in the changing drug compound landscape.
Full details and registration are here https://www.maggichurchouseevents.co.uk/bmcs/twenty-years-Ro5.htm.
2nd RSC-BMCS / RSC-CICAG Artificial Intelligence in Chemistry
The lineup for the 2nd RSC-BMCS / RSC-CICAG Artificial Intelligence in Chemistry Monday-Tuesday, 2nd to 3rd September 2019 Fitzwilliam College, Cambridge, UK has been updated.
Twitter #AIChem19
Artificial Intelligence is presently experiencing a renaissance in development of new methods and practical applications to ongoing challenges in Chemistry. Following the success of the inaugural “Artificial Intelligence in Chemistry” meeting in 2018, we are pleased to announce that the Biological & Medicinal Chemistry Sector (BMCS) and Chemical Information & Computer Applications Group (CICAG) of the Royal Society of Chemistry are once again organising a conference to present the current efforts in applying these new methods. The meeting will be held over two days and will combine aspects of artificial intelligence and deep machine learning methods to applications in chemistry.
Speakers
Deep learning applied to ligand-based de novo design: a real-life lead optimization case study, Quentin Perron, IKTOS, USA
A Turing test for molecular generators, Jacob Bush, GlaxoSmithKline, UK
Presentation title to be confirmed, Keynote: Regina Barzilay, Massachusetts Institute of Technology, USA
Artificial intelligence for predicting molecular Electrostatic Potentials (ESPs): a step towards developing ESP-guided knowledge-based scoring functions, Prakash Rathi, Astex Pharmaceuticals, UK
Molecular transformer for chemical reaction prediction and uncertainty estimation, Alpha Lee, University of Cambridge, UK
Drug discovery disrupted - quantum physics meets machine learning, Noor Shaker, GTN, UK
Presentation title to be confirmed, Christian Tyrchan, AstraZeneca,
Presentation title to be confirmed, Anthony Nicholls, OpenEye Scientific Software, USA
Deep generative models for 3D compound design from fragment screens, Fergus Imrie, University of Oxford, UK
DeeplyTough: learning to structurally compare protein binding sites, Joshua Meyers, BenevolentAI, UK
Presentation title to be confirmed, Maciej Haranczyk, IMDEA, Spain
Deep learning for drug discovery, Keynote: David Koes, University of Pittsburgh, USA
Presentation title to be confirmed, Olexandr Isayev, University of North Carolina at Chapel Hill, USA
Dreaming functional molecules with generative ML models, Christoph Kreisbeck, Kebotix, USA
Presentation title to be confirmed, Keynote: Adrian Roitberg, University of Florida, USA
Applications for poster presentations are welcomed, the closing date for submission is 5th July. A number of RSC-BMCS and RSC-CICAG student bursaries are available up to a value of £250, to support registration, travel and accommodation costs for PhD and post-doctoral applicants studying at European academic institutions. The closing date for bursary applications is 15th July.
Full details are on the conference website
Early Career MedChem Workshop
One of the highlights of the SCI/RSC Cambridge MedChem Meetings the Early Career MedChem Workshop, a satellite workshop consisting of a team-based exercise around a virtual medicinal chemistry programme will be held on the Sunday afternoon prior to this event, aimed at early career (up to 5 years’ experience) medicinal chemists. Registration for this event will be at no additional cost to the main meeting, Read the flyer here.
Registration is on the 20th SCI / RSC Medicinal Chemistry Symposium website
20th Cambridge MedChem meeting Registration open
I know the is eagerly anticipated because I have folder of email enquiries I can now respond to.
Registration for the 20th Cambridge MedChem Meeting is now open !!
https://www.soci.org/events/20th-scirsc-medicinal-chemistry-symposium.
Really is a fabulous lineup of speakers. Also includes Malcolm Campbell Memorial Prize presentation
20th Cambridge MedChem meeting
On 8-11 September 2019 we will be holding the 20th Cambridge Medicinal Chemistry Symposium, this marks a significant milestone for this meeting and the committee would like to use the opportunity to highlight some of the first disclosures of now important medicines and other events from the 40 year history of this meeting.
We have all the programmes from the 13th to 19th meetings, and I've managed to get details of the first meeting shown in this PDF. If you could share scanned copies of programme from the 2nd to 12th meetings it would be really great.
Also if you have particular memories of meetings you would be willing to share feel free to send an email.
Interesting meetings
In many companies/institutions/universities new arrivals are presented with a variety of desktop tools with little or no advice on how to use them other than "pick it up as you along". This workshop is intended to provide expert tutorials to get you started and show what can be achieved with the software.
The tutorials will be given a series of outstanding experts Christian Lemmen (BioSolveIT), Akos Tarcsay (ChemAxon), Giovanna Tedesco (Cresset), Dan Ormsby (Dotmatics) Greg Landrum (Knime ) and Matt Segall (Optibrium), you will be able to install the software packages on you own laptops together with a license to allow you to use it for a limited period after the event.
Registration opened just before Christmas and apparently there were a number of people sign up over the festive period. Remember there are a limited number of places and it is first come first served.
Registration and full details are here.
Also a free one-day symposium Streamlining Drug Discovery" in Frankfurt
The very successful symposia series "Streamlining Drug Discovery" comes to Frankfurt on 14 February 2019. Jointly BioSolveIT, Optibrium, Lhasa and Elsevier invite you for this free one-day event highlighting new approaches and technologies being applied to the search for future therapeutics. For further details please visit the symposium website https://www.biosolveit.de/symposium/2019-02-14/
20th SCI/RSC Medicinal Chemistry Symposium
20th SCI/RSC Medicinal Chemistry Symposium on 8 - 11 September 2019 at Churchill College, Cambridge.
Abstract deadline: Friday 9th November 2018
The organising committee wishes to solicit late-breaking, high impact medicinal chemistry talks to finalise the scientific programme. Potential contributions should be communicated to the secretariat at conferences@soci.org by Friday 9th November 2018. A number of conference places will be reserved for poster presenters and contributions are invited from the whole field of medicinal chemistry. Those presenting a poster may also elect to advertise their poster via oral presentation of a single slide 'flash' poster. Detailed procedures and submission deadlines for poster abstracts will be provided in the second announcement.
3rd RSC BMCS Medicinal Chemistry Symposium on Macrocycles
The full agenda for the Macrocycles 2018 meeting 8th-9th October 2018 is now available and it looks to be a great meeting.
Full details of the meeting and registration is available online here http://www.maggichurchouseevents.co.uk/bmcs/macrocycles_2018-online%20registration.htm.
20th SCI/RSC Medicinal Chemistry Symposium
The first circular for the 20th SCI/RSC Medicinal Chemistry Symposium (aka the Cambridge MedChem Meeting) has been announced. This is also a call for abstracts for both oral and poster submissions. Potential contributions should be communicated to the secretariat at conferences@soci.org by Friday 9th November 2018.
You can download the full details of the meeting here PDF.
A number of outstanding talks have already been confirmed.
RSC-BMCS / RSC-CICAG Artificial Intelligence in Chemistry
The lineup for the RSC-BMCS / RSC-CICAG conference on Artificial Intelligence in Chemistry has been announced.
Twitter hashtag - #RSC_AIChem
09.00 Registration, refreshments, and exhibition
10.00 Presentation title to be confirmed Marwin Segler, Benevolent AI, UK
10.30 Presentation title to be confirmed Nadine Schneider, Novartis, Switzerland
11.00 Refreshments, exhibition and posters
11.30 Keynote: What I learned about machine learning - revisited Bob Sheridan, Merck, USA
12.30 Lunch, posters and exhibition
14.00 Molecular de novo design through deep learning Ola Engkvist, AstraZeneca, Sweden
14.30 Scaling de novo design, from single target to disease portfolio Wilhem van Hoorn, Exscientia, UK
15.00 Refreshments, posters and exhibition
15.30 Investigating clusters in solvent data using K-means Ella Gale, University of Bristol, UK
16.00 Deep learning and chemical data Colin Batchelor, Royal Society of Chemistry, UK
16.30 Automation, analytics and AI Darren Green, Molecular Design UK, RD Platform Technology & Science, GlaxoSmithKline, UK
17.00 Drinks reception
18.00 Close
Friday, 15th June 2018, Royal Society of Chemistry at Burlington House, London, UK
Poster closing date is 13th April
Bursary closing date is 3rd May
Macrocycles 2018: 3rd RSC BMCS Medicinal Chemistry Symposium on Macrocycles
Take note of the closing dates for abstracts
Applications for oral and poster presentations are welcome. Posters will be displayed throughout the meeting and applicants should indicate whether they wish to be considered for a flash oral presentation when submitting an abstract (two minutes, single slide).The closing dates of 28th February (oral) and 8th August (poster).
PhD Student and Post-Doc Conference Bursaries
Did you know that most BMCS sponsored meetings have a number of bursaries available for PhD and post-doctoral students? Normally up to a value of £250, these awards help to cover registration and travel costs. Preference will be given to members of the RSC (and meeting co-sponsors if applicable), especially those who are selected to give posters.
Macrocycles 2018 meeting #BMCS_Macrocycles
Monday-Tuesday, 8th-9th October 2018, GlaxoSmithKline, Stevenage, UK
The objective of this symposium is to promote scientific interaction between scientists with a shared interest in the field of Macrocycles. This area is responsible for a growing number of therapeutic approaches and development candidates, all of which go ‘beyond the rule-of–five’. As a researcher in this field, come along to hear about the latest advances and also to share in some of the secrets of discovering therapeutic agents which go beyond Lipinski’s rules.
Full details and application forms are here http://www.maggichurchouseevents.co.uk/bmcs/Macrocycles-2018.htm.
Macrocycles 2018: 3rd RSC BMCS Medicinal Chemistry Symposium on Macrocycles
First announcement for the Macrocycles 2018 meeting #BMCS_Macrocycles
Monday-Tuesday, 8th-9th October 2018, GlaxoSmithKline, Stevenage, UK
The objective of this symposium is to promote scientific interaction between scientists with a shared interest in the field of Macrocycles. This area is responsible for a growing number of therapeutic approaches and development candidates, all of which go ‘beyond the rule-of–five’. As a researcher in this field, come along to hear about the latest advances and also to share in some of the secrets of discovering therapeutic agents which go beyond Lipinski’s rules.
Applications for oral and poster presentations are welcome. Posters will be displayed throughout the meeting and applicants should indicate whether they wish to be considered for a flash oral presentation when submitting an abstract (two minutes, single slide).The closing dates of 28th February (oral) and 8th August (poster).
Full details and application forms are here http://www.maggichurchouseevents.co.uk/bmcs/Macrocycles-2018.htm.
Neglected and Tropical Diseases Session at the 19th Cambridge MedChem Meeting
Update
I'm delighted to report that over 200 people have now watched the video online, looks like it was a valuable resource.
One of the nice things about my job is I get the chance to take part in some truly inspiring events. Last month I had the honour of chairing a session on Neglected and Tropical Diseases at the 19th Cambridge MedChem Meeting. In an effort of extend the exposure of the brilliant science undertaken in this important therapeutic area the conference organisers arranged for this to be a live webinar. The session was also recorded and is now available online.
This is a recording of the Neglected and Tropical Diseases Session at the 19th Cambridge MedChem Meeting, 11-13 September 2017. The speakers are Kelly Chibale (Univ of Capetown), Christoph Boss (Actelion), Rob Young (GlaxoSmithKline), Jonathan Large (LifeArc) and Charles Mowbray (DNDI).
Please feel free to share. #19thCamMedChem.
29th Symposium on Medicinal Chemistry in Eastern England
The Symposium on Medicinal Chemistry in Eastern England, known colloquially as the "Hatfield MedChem" meeting, is a highly successful, long-standing, one-day meeting which runs annually will be held 26 April 2018 09:30-17:00, Hatfield, United Kingdom
The Organising Committee are inviting abstract submissions for both oral and poster presentation. Please download an abstract template from the event website and return it the secretariat. Closing dates for submissions are:
24th November 2017 for oral abstracts
23rd February 2018 for poster abstract
19th Cambridge MedChem Meeting
The 19th RSC / SCI Medicinal Chemistry Symposium (#19thCamMedChem) takes place 10th-13th September 2017 at Churchill College, Cambridge, UK. This biennial meeting is one of the highlights of the drug discover calendar. Each meeting we try to enhance the scientific programme and this time there will be a live webcast of one of the sessions.
New for 2017 - Live Webcast Session on Neglected Tropical Diseases
Tuesday, 12th September Afternoon (13-30pm start).
Session Chair: Chris Swain, Consultant, UK
Introduction to the Neglected Tropical Diseases (NTD) session
Kelly Chibale, University of Capetown, South Africa
PI4K inhibitors that target multiple life cycle stages of the human malaria parasite
Kelly Chibale, University of Capetown, South Africa
Discovery and characterization of ACT-451840: an antimalarial drug with a novel mechanism of action
Christoph Boss, Actelion, Switzerland
Refreshments and short film clips
Rapid discovery of non-covalent inhibitors of DprE1, a novel and exciting target to treat Mycobacterium tuberculosis: impact of medicinal chemistry on an open source collaboration
Rob Young, GlaxoSmithKline, UK
Potent, selective and orally efficacious inhibitors of Plasmodium falciparum Protein Kinase G (PfPKG)
Jon Large, LifeArc, UK
First disclosure of a new oral development candidate for the treatment of visceral and cutaneous leishmaniasis
Charlie Mowbray, DNDi (Drugs for Neglected Diseases initiative), Switzerland
Closing remarks for NTD session
Charlie Mowbray, DNDi, Switzerland
The meeting is now fully booked but we hope that scientists around the world will be able to watch the presentations live using this link
Please feel free to share this link.
11th Biological and Medicinal Chemistry Postgraduate Symposium
Friday 8th December 2017, Department of Chemistry, University of Cambridge, Cambridge
Closing date for abstract submission is 15th September 2017
The Biological and Medicinal Chemistry Sector (BMCS) of the Royal Society of Chemistry will be hosting its 11th postgraduate symposium for PhD students and postdoctoral workers researching in biological or medicinal chemistry and related areas. The event will be held in the Department of Chemistry at the University of Cambridge on Friday 8th December 2017. Researchers working in these areas are invited to participate. Registration will start at 9:00 am with talks beginning at 10:00 am. The day will consist of 11 oral presentations (8 student and 3 keynote) plus a Flash Poster section. Each 20 minute student talk will be followed by 10 minutes for questions.
This is a fantastic meeting for anyone interested in medicinal chemistry and drug discovery, this event is FREE but all attendees should register as soon as possible and no later than the 1st December 2017.
19th RSC / SCI Medicinal Chemistry Symposium
The 19th RSC / SCI Medicinal Chemistry Symposium takes place 10th-13th September 2017 at Churchill College, Cambridge, UK. This biennial meeting is one of the highlights of the drug discover calendar. The full lecture timetable can be downloaded here.
Call for Posters
Contributions from the whole field of medicinal chemistry are invited. Flash presentation sessions are planned which will involve a two-minute presentation of poster highlights. Poster abstract submissions should be sent to the secretariat by 16th April if you wish to take advantage of the early-bird registration fee and indicate whether or not you would like to be included for consideration in the flash presentation session. The final deadline for submission of posters is 21st July.
Registration is now open and delegates are encouraged to book early to ensure places at this very popular meeting. Discounted rates are available to RSC and SCI student members, and some student bursaries are available. Applications are invited from PhD and post-doctoral students studying at European academic institutions, preferably members of the RSC, SCI or EFMC. Those submitting abstracts for poster presentation will be favoured. To apply for a student bursary, please complete and return the bursary application form by 21st July.
The BMCS Mastering MedChem III: 3rd RSC-BMCS symposium on mastering medicinal chemistry
This meeting is aimed at all those who wish to become better drug hunters and heed warnings from the past. (22 March 2017 09:00-19:00, Cardiff Bay, United Kingdom).
In the main there are two types of drug discovery programmes: those that hit serious problems and those that are going to hit serious problems. The difference between success and failure is how we, as medicinal chemists, tackle and resolve the problems
Sounds a great meeting both for those starting out in their careers and for those looking to pick up new tips.
28th symposium on Medicinal Chemistry in Eastern England
28th symposium on Medicinal Chemistry in Eastern England, Thursday 27th April 2017, The Fielder Centre, Hatfield, Hertfordshire, UK
Organised by RSC-BMCS (Royal Society of Chemistry – Biological and Medicinal Chemistry Sector)
Programme
09.00 Registration, refreshments and exhibition
Session chair: Adrian Hall, UCB
09.30 Opening remarks
Nicole Hamblin, GlaxoSmithKline
09.35 From phenotypic hit to a validated target for tuberculosis
Robert Bates, GlaxoSmithKline
10.10 Discovery of potent inhibitors of the lysophospholipase autotaxin
Prit Shah, Cancer Research Technology
10.45 Refreshments and exhibition
11.15 Development of Tesirine: a clinical antibody-drug conjugate pyrrolobenzodiazepine payload: medicinal chemistry at the frontier between small molecules and biologics
Arnaud Tiberghien, Spirogen
11.50 NMR conformational analysis in molecular design – case studies and impact
Martin Packer, AstraZeneca
12.25 Highly potent cell-penetrant inhibitors of the KEAP1-NRF2 protein-protein interaction via X-ray fragment screening
Charlotte Griffiths-Jones, Astex Pharmaceuticals
13.00 Lunch and exhibition
Session Chair: Simon Ward, University of Sussex
14:05 Selective on-target chemical probes of protein-protein interactions
Alessio Ciulli, University of Dundee
14.40 Solid state studies of a preclinical candidate in a CRO environment: the importance of de-risking early
Russell Scammell, Charles River
15.15 Refreshments and exhibition
15.45 Drug discovery case study
Tom Miller, Shire
16.20 Optimisation of a series of novel smoothened inhibitors
Matilda Bingham, RedX
16.55 Concluding remarks
17.00 Close
Fragments 2017
Fragment-based screening is now a well established methodology for the identification of leads for drug discovery and the aim of the 6th RSC-BMCS Fragment-based Drug Discovery meeting will be to continue the focus on case studies in Fragment-based Drug Discovery that have delivered compounds to late stage medicinal chemistry, preclinical or clinical programmes.
6th RSC-BMCS Fragment-based Drug Discovery meeting
Sunday to Tuesday, 5th to 7th March 2017
at Parkhotel Schönbrunn, Vienna, Austria
Full details and registration are online.
Cheminformatics for Drug Design: Data, Models & Tools
Still a few places left at the Cheminformatics for Drug Design: Data, Models & Tools meeting organised by SCI's Fine Chemicals Group and RSC's Chemical Information and Computer Applications Group has been extended.
Imperial War Museum, Duxford, UK Wednesday 12 October 2016
Full details are available here https://www.soci.org/Events/Display-Event?EventCode=FCHEM481
Sounds an excellent meeting and you will have a chance to look around the aircraft at the Duxford Imperial War Museum.
Two conferences that might be of interest
| Event | FBLD 2016 (Fragment-based Lead Discovery Conference 2016) |
|---|---|
| Place | Cambridge, Massachusetts, USA |
| Dates | 9th-12th October 2016 |
| Website | http://www.ysbl.york.ac.uk/fbld/2016/ |
| Poster abstracts | Closing date is 30th September |
| Event | Fragments 2017 - 6th RSC-BMCS Fragment-based Drug Discovery meeting |
| Dates | Sunday to Tuesday, 5th to 7th March 2017 |
| Place | Parkhotel Schönbrunn, Vienna, Austria |
| Websites | http://www.maggichurchouseevents.,co.uk/bmcs |
| also | http://www.rsc.org/events/detail/23352/fragments-2017-7th-rsc-bmcs-fragment-based-drug-discovery-meeting |
Cheminformatics for Drug Design: Data, Models & Tools
I’ve just heard that the poster deadline for the Cheminformatics for Drug Design: Data, Models & Tools meeting organised by SCI's Fine Chemicals Group and RSC's Chemical Information and Computer Applications Group has been extended.
Imperial War Museum, Duxford, UK Wednesday 12 October 2016
Full details are available here https://www.soci.org/Events/Display-Event?EventCode=FCHEM481
Sounds an excellent meeting and you will have a chance to look around the aircraft at the Duxford Imperial War Museum.
19th RSC/SCI Medicinal Chemistry Symposium
I’m delighted to highlight the first announcement of the 19th RSC/SCI Medicinal Chemistry Symposium to be held in Cambridge in September 2017. Europe’s premier biennial Medicinal Chemistry event, focusing on first disclosures and new strategies in medicinal chemistry.
Solutions for Drug-Resistant Infections Meeting
SDRI 2017 is a multi-disciplinary scientific conference for the Asia Pacific region focused on Solutions for Drug Resistant Infections. This inaugural conference theme is New Drugs for Drug-Resistant Infections. The conference will take place at the Brisbane Convention and Exhibition Centre in Australia from 3 - 5 April, 2017.
The program is expected to attract 400 international participants and will provide a fantastic forum for researchers and industry representatives working in the space of microbiology, virology, parasitology, genomics, pharmacology and medicinal chemistry, to network and discuss new ways to solve the global challenge of drug-resistant infections. Our goal for SDRI 2017 is to lead a concerted discussion to set three priorities and guide research efforts towards global solutions for drug resistance research.
Conference themes:
- Antimicrobial drug discovery
- Improvements to existing anti-infective agents and repurposing
- New Drug Targets
- Alternate therapies
- Navigating the pipeline
- International Models and Funding
- Vector control and vaccines
International keynote speakers confirmed:
- Professor Dame Sally Davies DBE FMedSci FRS, Chief Medical Officer for England
- Professor Ramanan Laxminarayan, Director for Center for Disease Dynamics, Economics & Policy (CDDEP), Washington and Vice-President for Research & Policy at Public Health Foundation of India (PHFI)
RSC symposium on Late Stage Functionalization for Synthesis and Medicines
RSC symposium on Late Stage Functionalization for Synthesis and Medicines
Date Monday, 5th December 2016 Place Mathematical Institute, Andrew Wiles Building, Oxford, U Organisers RSC-BMCS (Royal Society of Chemistry – Biological and Medicinal Chemistry Sector)
Late Stage Functionalization (LSF) holds the potential to revolutionise the logic of chemical synthesis and open new ways to prepare novel natural products and medicines. The introduction of important chemical groups for medicinal chemistry in the very last steps of the synthesis through LSF could also dramatically speed up the preparation of NCEs and have a major impact on drug discovery. The availability of new powerful catalytic chemistries showing a high degree of functional group tolerance and that can be performed under mild conditions offer tremendous opportunities for chemists to access new molecules that cannot be made easily by conventional approaches.
Cheminformatics for Drug Design: Data, Models & Tools
A joint meeting Organised by SCI's Fine Chemicals Group and RSC's Chemical Information and Computer Applications Group
18th SCI/RSC Medicinal Chemistry Symposium
18th SCI/RSC Medicinal Chemistry Symposium Sunday 13 - Wednesday 16 September 2015 Churchill College, Cambridge , UK
Europe’s premier biennial Medicinal Chemistry event, focusing on first disclosures and new strategies in medicinal chemistry. Reflecting current trends in medicinal chemistry and pharmaceutical research, the theme of the conference will be ‘Drugging the Undruggable’.
A number of conference places will be reserved for poster presenters and contributions are invited from the whole field of medicinal chemistry. Those presenting a poster may also elect to advertise their poster via oral presentation of a single slide ‘flash’ poster. In addition to traditional plenary talks the organising committee wishes to solicit short talks (20 minutes) describing highly impactful but possibly less complete episodes of medicinal chemistry.
Further Information SCI Conference Dept, 14/15 Belgrave Square, London, SW1X 8PS T: + 44 (0)20 7598 1561 E: conferences@soci.org W: www.soci.org
Biological and MedChem Meeting
I just got details of an interesting meeting in Cambridge, UK later this year.
17th RSC/SCI Medicinal Chemistry Symposium
The registrations are coming in for the forthcoming 17th RSC/SCI Medicinal Chemistry Symposium to be held in Cambridge UK (8-11 Sept 2013). Book early to avoid disappointment.
Full details of the scientific programme are available here together with the registration form.
17th RSC/SCI Medicinal Chemistry Symposium
The latest details of the forthcoming 17th RSC/SCI Medicinal Chemistry Symposium to be held in Cambridge UK (8-11 Sept 2013) are now available.
Full details of the scientific programme are available here together with the registration form.
16th SCI/RSC Medicinal Chemistry Symposium
The deadline for the early bird rates ends soon for the 16th SCI/RSC Medicinal Chemistry Symposium to be held Sunday 11 -14 September 2011 Churchill College, Cambridge, UK.
The 16th SCI-RSC Medicinal Chemistry Symposium will focus on first disclosures and new strategies in medicinal chemistry. Reflecting current trends in medicinal chemistry and pharmaceutical research, the theme of the conference will be The Path Forward: Collaboration or Competition? The scientific programme features lectures on Enzyme Inhibitors, Ligands for Receptors and Ion Channels plus a Hot Topic late breaker session. In addition the meeting has a number of talks addressing key Enabling Processes and Technologies for the future of Medicinal Chemistry. There will also be Poster Sessions with a number of posters selected for short talks.
RSC MedChem School
The details of the RSC MedChem School that will be held 4-8 July 2011 at Burleigh Court Conference Centre, Loughborough University are now online. Early bird registration is available until April 1st.
Full details can be found on the RSC website here.
The residential training school focusses on current thinking in drug discovery and will take place at the Burleigh Court Conference Centre, Loughborough University. The course is directed primarily at graduate and post doctoral chemists with 1-4 years experience in the field of drug research. Final year PhD students in pharmacy and organic chemistry contemplating a career in medicinal chemistry will also find the course of use.
16th SCI/RSC Medicinal Chemistry Symposium
The flyer containing details of and the application form for the 16th SCI/RSC Medicinal Chemistry Symposium to be held Sunday 11 -14 September 2011 Churchill College, Cambridge, UK is now available for download:
FINAL CIRCULAR and APPLICATION FORM
The 16th SCI-RSC Medicinal Chemistry Symposium will focus on first disclosures and new strategies in medicinal chemistry. Reflecting current trends in medicinal chemistry and pharmaceutical research, the theme of the conference will be The Path Forward: Collaboration or Competition? The scientific programme features lectures on Enzyme Inhibitors, Ligands for Receptors and Ion Channels plus a Hot Topic late breaker session. In addition the meeting has a number of talks addressing key Enabling Processes and Technologies for the future of Medicinal Chemistry. There will also be Poster Sessions with a number of posters selected for short talks
Call for Posters
Contributions from the whole field of medicinal chemistry are invited. Please submit A4 abstracts of your poster presentation to jacqui.colgate@soci.org and indicate whether you are willing to be upgraded to a poster talk. Deadline for submissions: 27 May 2011.
RSC MedChem School
The RSC Medicinal Chemistry Summer School, for the last 40 years regarded as the pre-eminent industry training course for medicinal chemists, is due to take place 4-8th July 2011 at Burleigh Court Conference Centre, Loughborough University. It brings together cross-industry and cross-discipline practitioners to provide lectures, tutorials , workshops and case-studies illustrating modern drug discovery. This will provides an excellent training opportunity for young medicinal chemists, a refresher for those more experienced, or an introduction to drug design thinking for any scientist working in cross-functional discovery teams.
RSC MedChem School
The details of the RSC MedChem School that will be held 4-8 July 2011 at Burleigh Court Conference Centre, Loughborough University are now online. Early bird registration is available until April 1st.
Full details can be found on the RSC website here.
The residential training school focusses on current thinking in drug discovery and will take place at the Burleigh Court Conference Centre, Loughborough University. The course is directed primarily at graduate and post doctoral chemists with 1-4 years experience in the field of drug research. Final year PhD students in pharmacy and organic chemistry contemplating a career in medicinal chemistry will also find the course of use.
16th RSC-SCI Medicinal Chemistry Symposium
The first circular for the 16th RSC-SCI Medicinal Chemistry Symposium, 11-14 September 2011, Churchill College, Cambridge, UK is now available here.
Scientifc Program includes:-
Strategies to success - H-PGDS inhibitors for the treatment of inflamatory disorders, Sukanthini Thurauratnam, Sanofi -Aventis
Discovery on next generation glucokinase activators, Mike Waring, AstraZeneca
Inhalation by design, Paul Glosson, Pfizer
Bromodomains a new class of epigenetic targets for small molecule drug discovery, Jason Witherington, GSK
GPCR Structure based drug design using stabilised receptors(StaRs), Miles Congreve, Heptares
GS-9350: a novel pharmacoenhancer, Lianhong Xu, Gilead Sciences