Cambridge MedChem Consulting

Lead Identification

This is the process whereby ‚”Hits” from screening are transformed into ‚ “Leads” that can be then used for “Lead Optimisation” This could be a single screening hit or homologous group of hits, or lead from literature. But High-through-put screening can deliver multiple discrete series the critical decision is which hit(s) to focus on. Some companies use the term Hit to Lead (het2lead) group.

What makes a good Lead

Remember Potency is usually the most easily optimised property

14 December 2015