The fantastic resource ChEMBL has been updated. ChEMBL 32 contains

• 2,354,965 compounds (of which 2,327,928 have mol files)
• 2,995,433 compound records (non-unique compounds)
• 20,038,828 activities
• 1,536,903 assays
• 15,139 targets
• 86,364 documents

More details are here http://chembl.blogspot.com/2023/03/chembl-32-is-released.html.

Data can be downloaded from the ChEMBL FTP site.