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Cambridge MedChem Consulting

Known Fragment Hits

I’ve just updated the section describing fragment hits reported in the literature.The dataset now has >500 entries culled from 150 publications directed at nearly 100 different molecular targets using 18 different detection technologies and might be expected to give some insight into the type of compounds that appear as hits.

I’ve calculated a number of physicochemical descriptors and identified fragments that have appeared as hits against multiple targets.