Cambridge MedChem Consulting

Selected Publications

Alice E. Williamson, Paul M. Ylioja, Murray N. Robertson, Yevgeniya Antonova-Koch, Vicky Avery, Jonathan B. Baell, Harikrishna Batchu, Sanjay Batra, Jeremy N. Burrows, Soumya Bhattacharyya, Felix Calderon, Susan A. Charman, Julie Clark, Benigno Crespo, Matin Dean, Stefan L. Debbertγ, Michael Delves, Adelaide S. M. Dennis, Frederik Deroose, Sandra Duffy, Sabine Fletcher, Guri Giaever, Irene Hallyburton, Francisco-Javier Gamo, Marinella Gebbia, R. Kiplin Guy, Zoe Hungerford, Kiaran Kirk, Maria J. Lafuente-Monasterio, Anna Leeη, Stephan Meister, Corey Nislow, John P. Overington, George Papadatos, Luc Patiny, James Pham, Stuart A. Ralph, Andrea Ruecker, Eileen Ryan, Christopher Southan, Kumkum Srivastava, Chris Swain, Matthew J. Tarnowski, Patrick Thomson, Peter Turner, Iain M. Wallace, Timothy N. C. Wells, Karen White, Laura White, Paul Willis, Elizabeth A. Winzeler, Sergio Wittlin, and Matthew H. Todd, Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles, ACS Cent. Sci., 2016, 2 (10), pp 687–701

C. J. Swain, Data Analysis and Visualization Tools, Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, 2016, ISBN 978-0-12-409547-2

P. Patrizia Mangione, Stéphanie Deroo, Stephan Ellmerich, Vittorio Bellotti, Simon Kolstoe, Stephen P. Wood, Carol V. Robinson, Martin D. Smith, Glenys A. Tennent, Robert J. Broadbridge, Claire E. Council, Joanne R. Thurston, Victoria A. Steadman, Antonio K. Vong, Christopher J. Swain, Mark B. Pepys, Graham W. Taylor. Bifunctional crosslinking ligands for transthyretin, Open Biol. 2015 5 150105

Dr E. Zartler, Dr C. Swain & S. Pearce. Fragment library design: the evolution of fragment-based lead discovery Drug Discovery World, Winter 2012/13

Swain C J, Big Pharma in Crisis. European Pharmaceutical Contractor June 2012 12-16

Swain C J, Teran A, Maroto M, Cabello A. (2006) Identification and optimisation of 5-amino-7-aryldihydro-1,4-diazepines as 5-HT(2A) ligands. Bioorganic & Medicinal Chemistry Letters 16 6058–606.

Swain C J. (2006) iBabel, CDK News 3(1), 19-20.

Raubo, P, Kulagowski, J J, Swain, C J. (2003) A stereoselective synthesis of (±)-3-aryl-6-phenyl-1-oxa-7-azaspiro[4.5]-decanes. Synlett (13), 2021-2024.

Harrison T, Owens A P Williams B J, Swain C J, Williams A, Carlson E J, Rycroft W, Tattersall F D, Cascieri M A, Chicchi G G, Sadowski S; Rupniak N M, Hargreaves R J. (2001) An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration. Journal of Medicinal Chemistry, 44(24), 4296-9.

Swain C J, Rupniak N M J. (1999) Progress in the Development of Neurokinin Antagonists. Annual Reports in Medicinal Chemistry 34 51-60.

Harper S, Bilsand J, Young L, Bristow L, Boyce S, Mason G, Rigby M, Hewson L, Smith D, O'Donnell R, O'conner D, Hill R G, Evans D, Swain C, Williams B, Hefti F. (1998) Analysis of the neurotrophic effects of GPI-1046 on neuronal survival and regeneration in culture and in vivo. Neuroscience 88, 1, 257

Ladduwahetty T, Swain C J, Keown L, Seward E M, Haworth K, Owen S, Chambers M, Baker R, Cascieri M A, Hargreaves R J, Iversen L L, MacIntyre D E, Metzger J M, Sadowski S, Shepheard S, Strader C D, Tattersal F D, (1996) L-741,671: A potent orally active human NK1 antagonist. J. Med. Chem. 39(15), 2907-2914.

Cascieri M A, Shiao L, Mills S G, MacCoss M, Swain C J, Yu H, Ber E, Sadowski S, Wu M T, Strader C D, Fong T M. (1995) Characterisation of the Interaction of Diacylpiperazine Antagonists with the human NK1 receptor: Identification of a Common Binding site for structurally Dissimilar Antagonists. Mol. Pharm. 47(4), 660.

MacLeod A M, Merchant K J, Brookfield F, Kelleher F, Stevenson G, Owens A P, Swain C J, Cascieri M A, Sadowski S, Ber E, Strader C D, Macintyre D E, Metzger J M, Ball R G, Baker R. (1994) Identification of L-Tryptophan Derivatives with Potent and Selective Activity at the NK1 receptor. J. Med. Chem. 37, 1269.

Cascieri M A, Fong T M, Yu H, Bansai A, Swain C J, Strader C D. (1993). Amino-aromatic interaction between histidine 197 of the NK1 receptor and CP 96345. Nature 362, 350.

Jenkins P, Symons M C R, Booth S E, Swain C J. (1992) Why is a vinyl anion configurationally stable but a vinyl radical configurationally unstable. Tet. Lett. 33, 3543.

Swain C J, Baker R, Kneen C, Herbert R, Moseley J, Saunders J, Seward E M, Stevenson G I, Beer M, Stanton J, Watling K, Ball R G. (1992) Novel 5-HT3 Antagonists: Indol-3-ylspiro(azabicycloalkane-3,5(4H)-oxazoles). J Med. Chem. 35, 1019.

Swain C J, Baker R, Kneen C, Moseley J, Saunders J, Seward E M, Stevenson G, Beer M, Stanton J, Watling K. (1991) Novel 5 HT3 Antagonists. Indole Oxadiazoles. J. Med. Chem. 34, 140.

Baker R, Boyes A L, Swain C J. (1990) Synthesis of Talaromycins A, B, C and E. J. Chem. Soc. Perkin Trans 1, 1415.

Baker R, O'Mahony M J, Swain C J. (1987) The total synthesis of (+) Milbemycin B3. J. Chem. Soc. Perkin Trans. 1, 1623.

Baker R, Cotterell I F, Ravenscroft P D, Swain C J. (1985) The total synthesis of Ancistrofuran. J. Chem. Soc. Perkin Trans. 1, 2463.

Baker R, O'Mahony M J, Swain C J. (1984) The total synthesis of Wintermoth Pheromone. J. Chem. Res. 190

A full list of all 140 publications.