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Cambridge MedChem Consulting

No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples

For depression, SLC6A4 seemed like a great candidate and was supported by very early gene studies


Am J Psychiatry. 2019 May 1;176(5):376-387. DOI

The study results do not support previous depression candidate gene findings, in which large genetic effects are frequently reported in samples orders of magnitude smaller than those examined here. Instead, the results suggest that early hypotheses about depression candidate genes were incorrect and that the large number of associations reported in the depression candidate gene literature are likely to be false positives.

How many other early gene disease association studies need to be checked?