Chiral Fragment Screening
One of the attractions of fragment-based screening is that “Fragment Space” is smaller than “Chemical Space” and can be more effectively probed with a relatively small library. However, if we include chiral fragments the size of the library increases, as does the complexity of the ligands. It can also add extra work if the individual enantiomers of a chiral fragment are not available.
The poll linked below is intended to try and capture the current view. I'll post the results here later.