I've been a tutor at the RSC MedChem School on a number of occasions and I can say this is an excellent opportunity for scientists new to drug discovery to benefit from an understanding of all aspects of the drug discovery process, from target and hit identification, through ADME and computational chemistry, to patents and safety studies.
The 2017 Medicinal Chemistry Residential School takes place 11 - 16 June, Loughborough UK, it is always very popular so well worth signing up early.
The 2017 Residential School will take place over 5 days and content is delivered by experts in the field from industry and academia. The programme includes lectures focusing on the fundamental principles of drug discovery, hands-on tutorials allowing delegates to put into practice what they have learnt and case histories from previous drug discovery projects. The programme will also include an evening lecture from a distinguished speaker. Throughout the week course tutors and speakers will be available for informal discussion and there will be plenty of opportunities to network with the broad range of academic and industrial researchers in attendance.
During 2016 Global Health are running a series of webinars on the subject of compound design. The programme for future meetings is available below (the agenda will develop through the year).
Date Agenda (& timing of each item in the recording when available)
21st Jan 2016
Introduction to meetings, Mark Gardner Application of PK Tools in the optimisation of a series for the treatment of leishmaniasis, Gavin Whitlock, Sandexis, working with DNDi Hints and tips to working with DataWarrior, Isabelle Giraud, Actelion, slides Isabelle Giraud, DataWarrior demonstration" Recording
25th Feb 2016
Visceral leishmaniasis TCP & screen sequence, Charlie Mowbrary, DNDi Malaria Target Candidate Profiles, stage gates and implications for successful malaria drug discovery, Paul Willis, MMV Registration
17th Mar 2016 "DataWarrior advanced data analysis, Isabelle Giraud, Actelion Using the RSC Medicinal Chemistry Toolkit in Drug Discovery Projects, Andy Davis, AZ The RSC Medicinal Chemistry Toolkit is a free suite of resources to support the day-to-day work of drug discovery scientists. It was developed to provide difficult-to-access, but industry-validated tools in a portable format. The presentation will show with worked examples, how the RSC Medicinal Chemistry Toolkit (Apple only) can be used to support design strategy thinking and structure-activity optimization. https://itunes.apple.com/gb/app/medicinal-chemistry-toolkit/id910073742?mt=8" Registration
21st Apr 2016
Free data pipelining tool KNIME in compound design & analysis Introduction to KNIME & use cases in drug discovery – further details tbd Registration
There are more details here.
I’ve just been sent details of a new medicinal chemistry course.
This course explores how to bring a drug from concept to market, and how a drug's chemical structure relates to its biological function. The course opens with an introduction to the drug approval process. This introduction combines the social, economic, and ethical aspects of drug discovery. Topics include how diseases are selected for treatment, the role of animal testing, and the costs of various discovery phases. The course then focuses on the scientific side of drug discovery. Topics include how drugs interact with biological molecules, drug absorption and elimination, and the discovery of weakly active molecules and their optimization into viable drugs.
The course starts 10 March, it is estimated the course will require 6-8 hours per week and runs for 7 weeks. The course was organised by Erland Stevens who wrote the medchem textbook Medicinal Chemistry: The Modern Drug Discovery Process.