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Cambridge MedChem Consulting

Lysosome Targeting Chimeras (LYTACs)

A while back I added a page on PROteolysis Targeting Chimera (PROTAC) a technology using the ubiquitin proteasome system to induce degradation of the target protein DOI. However this technology is limited to cytosolic proteins.

A recent publication highlights a new technology "Lysosome Targeting Chimeras (LYTACs) for the Degradation of Secreted and Membrane Proteins" DOI that further extends the protein degradation options.

Targeted protein degradation is a powerful strategy to address the canonically undruggable proteome. However, current technologies are limited to targets with cytosolically-accessible and ligandable domains. Here, we designed and synthesized conjugates capable of binding both a cell surface lysosome targeting receptor and the extracellular domain of a target protein…. LYTACs represent a modular strategy for directing secreted and membrane proteins for degradation in the context of both basic research and therapy.