When I first started on my career I was only to well aware that funding bodies would reject proposals for having "not enough chemistry" or "not enough biology" but I had hoped that by now it would be realised that multidisciplinary teams were key elements in bleeding edge science. However this recent paper suggests the problem still persists. Anyone who has been involved in drug discovery will understand the importance of interdisciplinary research
Point of View: Correcting the bias against interdisciplinary research DOI
When making decisions about funding and jobs the scientific community should recognise that most of the tools used to evaluate scientific excellence are biased in favour of established disciplines and against interdisciplinary research.
Scientists who leave the safe haven of their home discipline to explore the uncharted territory that lies outside and between established disciplines are often punished rather than rewarded for following their scientific curiosity
Perhaps all funding bodies should read this book
The book is the basis for "The Medici Effect," a term coined by Johansson and used throughout various industries to describe innovation that happens when disciplines and ideas intersect.
What is Wellcome Open Research?
- A platform for Wellcome-funded researchers to rapidly publish any research outputs they wish to share.
- Supports reproducibility and transparency.
- Uses an open research publishing model: immediate publication followed by open invited peer review.
- Includes all supporting data, enabling reanalysis, replication and reuse.
I've been working with the BioFocus group at Chesterford Park (now part of Charles River) thinking about ligands for Protein Protein Interactions, some of the work was described on a poster at the 18th Cambridge Medicinal Chemistry Meeting held in Cambridge in September this year. The poster is now available online http://www.criver.com/files/pdfs/nonsource/do-privileged-ppi-scaffolds-exist.aspx
Protein-protein interactions (PPIs) are ubiquitous in cellular biochemistry; however they are often difficult drug targets to interrogate due to their unique molecular topologies. A consequence is that low hit rates are frequently observed in PPI HTS campaigns and there remains an unmet need for innovative small molecule PPI inhibitors (SMPPIIs). The term "privileged scaffold" was coined in 1988 when core structures were found to bind to more than one receptor with high affinity. This led us to pose the question: “Do privileged PPI scaffolds exist?”
A brilliant group of scientists to work with, many stimulating discussions in a very important area.
Fragment library design: the evolution of fragment-based lead discovery
By Dr E. Zartler, Dr C. Swain & S. Pearce
Drug Discovery World Winter 2012/13
With the growing need to streamline the drug discovery process, screening against fragment libraries rather than drug-like molecules has become increasingly adopted as an integral part of many drug discovery programmes. However, success depends on the quality of the fragment library, and many factors dictate quality.